Side Effects of Flexeril cyclobenzaprine: Interactions & Warnings

Side Effects of Flexeril cyclobenzaprine: Interactions & Warnings

If you notice any of these symptoms in your elderly loved one, it’s important to speak with their healthcare provider right away. Long-term use of NSAIDs may cause peptic ulcer disease, or bleeding from the stomach or intestine unless another drug is also given to protect the stomach. NSAIDs and celecoxib can also worsen kidney function and symptoms of heart failure. Estrogens increase the risk of breast and uterine (endometrial) cancer and may increase the risk of stroke, heart attack, and dementia in older women. Vaginal estrogen products seem to be safe and effective to treat painful intercourse, urinary tract infections, and other vaginal symptoms. These drugs can cause drowsiness and loss of balance when a person is walking.

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Your first-line treatment will still be over-the-counter pain relievers like acetaminophen (Tylenol) and non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) and naproxen (Aleve). The regular tablet’s usual dosage is two to four times a day, while the extended release capsule is generally taken one to two times a day. The usual starting dose, according to the Drug Enforcement Administration, is 5 mg three times a day. The maximum recommended dose is 10 mg three times a day. Taking this drug with an MAOI or within 14 days of stopping an MAOI could increase your risk of serious side effects.

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The usual dose is 5–10mg three times daily and treatment for more than 2–3 weeks is not recommended. Elderly patients are more susceptible to the side effects of Flexeril due to age-related changes in their bodies. Flexeril is prescribed to treat short-term pain and discomfort that stems from muscle injuries, including strains, sprains, and spasms. It is usually used in conjunction with physical therapy. The medication helps control the muscle spasms that result in pain. Typically, a doctor will prescribe Flexeril as part of a treatment plan that also includes rest and physical therapy.

Analysis of the data from controlled studies shows that FLEXERIL produces clinical improvement whether or not sedation occurs. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment).

  • When given to people with dementia, antipsychotic drugs increase the risk of stroke and death.
  • This means you may need to take it with other medications.
  • Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin).

People should avoid tasks that necessitate alertness until they know how Flexeril will affect them. Some people may not feel drowsiness at all, while others may feel it intensely. Other common Flexeril side effects include nausea, dry mouth, and dizziness. It works by preventing nerve impulses (or pain sensations) from reaching your brain.


After graduating with a Bachelor of Arts in psychology and women’s studies, she earned a Master of Science in clinical health psychology and a Master of Public Health in maternal-child health. Her interests include oncology, women’s health and exercise science. Talk to your doctor about any bowel trouble you have while taking cyclobenzaprine; your dosage may need to be reduced, or your dosing schedule may be changed to treat your constipation. Do not stop taking your medication without first talking with your physician. Drink plenty of fluids, even if you do not feel thirsty. You may be sleeping a lot due to the pain or the medication, but it is important to stay hydrated throughout the day.

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The patient remained agitated for 48 hours after presentation and required frequent sedation. Urine output dropped and creatinine rose to 1.8 twenty four hours into his admission, this responded to fluid boluses and creatinine thereafter trended towards normal. His mental status improved gradually to being fully oriented on day 4 and he was transferred to a floor bed. A psychiatry consult opined he wasn’t actively suicidal. He was discharged on day 6 and on follow up in the clinic a week thereafter was doing well with no active issues. We present this case as an example of the range of cyclobenzaprine toxicity and underline the treatment protocols used.

For most patients, the recommended dose of Flexeril is 5 mg three times a day. The dosage is based on your medical condition and response to treatment. This medication should only be used short-term (for 3 weeks or less) unless directed by your doctor. how many hours between doses of flexeril Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

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For example, carisoprodol is not recommended during pregnancy, as it may harm the fetus. Taking muscle relaxers increases the risk of experiencing adverse side effects, and that too is not just limited to the mother; it can affect the baby as well. Despite that the majority of them are listed in C pregnancy category, some of the side effects can be lower milk supply, excessive sleepiness in infants, etc. Drug interactions of Flexeril include tricyclic antidepressants because Flexeril is chemically related to this class of drugs. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin).

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